Electrophysiological Motor Unit Number Estimation (MUNE) Measuring Compound Muscle Action Potential (CMAP) in Mouse Hindlimb Muscles
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چکیده
منابع مشابه
Electrophysiological Motor Unit Number Estimation (MUNE) Measuring Compound Muscle Action Potential (CMAP) in Mouse Hindlimb Muscles
Compound muscle action potential (CMAP) and motor unit number estimation (MUNE) are electrophysiological techniques that can be used to monitor the functional status of a motor unit pool in vivo. These measures can provide insight into the normal development and degeneration of the neuromuscular system. These measures have clear translational potential because they are routinely applied in diag...
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[1] Benatar M, Hammad M, Doss-Rinev H. Concentric-needle fiber electromyografy for the diagnosis of myasthenia gravis. Muscle Nerve 2006; 34: 163–168 [2] Bischoff C. Bedeutung der Einzelfaser-Elektromyografie für die Diagnostik neuromuskulärer Erkrankungen. Klin Neurophysiol 2000; 31: 136–143 [3] Bischoff C. Einzelfaser-EMG mit konzentrischen Nadelelektrode: eine Alternative in der Diagnositik ...
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OBJECTIVE To evaluate the clinical significance of motor unit number estimation (MUNE) and quantitative analysis of motor unit action potential (MUAP) in carpal tunnel syndrome (CTS) according to electrophysiologic severity, ultrasonographic measurement and clinical symptoms. METHOD We evaluated 78 wrists of 45 patients, who had been diagnosed with CTS and 42 wrists of 21 healthy controls. Me...
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Motor units (MUs) reflect the function of the central nervous motor system. Thus, the estimated MU number is a good option to investigate the functional movement disorder in the Parkinson’s disease (PD). The purpose of this study was to compare the estimated MUs number in the medial gastrocnemius (MG) muscle of the normal rats and those with the Parkinsonism. The MG muscle of two age-matche...
متن کاملElectrophysiological biomarkers in spinal muscular atrophy: proof of concept
OBJECTIVE Preclinical therapies that restore survival motor neuron (SMN) protein levels can dramatically extend survival in spinal muscular atrophy (SMA) mouse models. Biomarkers are needed to effectively translate these promising therapies to clinical trials. Our objective was to investigate electrophysiological biomarkers of compound muscle action potential (CMAP), motor unit number estimatio...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2015
ISSN: 1940-087X
DOI: 10.3791/52899